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Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique D.m. Patel
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Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique
D.m. Patel
Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.
| Mídia | Livros Paperback Book (Livro de capa flexível e brochura) |
| Lançado | 13 de fevereiro de 2014 |
| ISBN13 | 9783846504055 |
| Editoras | LAP LAMBERT Academic Publishing |
| Páginas | 124 |
| Dimensões | 150 × 7 × 226 mm · 190 g |
| Idioma | Inglês |