Tetracyclines and Macromolecule: Binding and Damaging Properties of Tetracyclines to Albumin and Dna - Mateen Khan - Livros - LAP LAMBERT Academic Publishing - 9783844393224 - 3 de maio de 2011
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Tetracyclines and Macromolecule: Binding and Damaging Properties of Tetracyclines to Albumin and Dna

Mateen Khan

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Tetracyclines and Macromolecule: Binding and Damaging Properties of Tetracyclines to Albumin and Dna

Tetracyclines are well known broad spectrum antibiotics, bind with macromolecules (serum albumin and DNA). The higher binding affinity of tetracyclines for macromolecules in the body is implicated in drug stability and potency with a potential risk of macromolecular damage due to intracellular accumulation of tetracyclines. Photo- oxidation of TCs produces reactive oxygen species. Reactive oxygen species not only damage the protein but also induce strand breaks in DNA. Direct binding of tetracyclines with DNA, inducing the conformational changes, and the concomitant reduction of Cu(II), involving the formation of free radicals contribute for the strand breakage. There by indicating the essential role of hydroxyl radicals in the DNA breakage in addition to the methylation at N-3 and N-7 position of purine (A&G) which resulted mismatched of the base pairs. Thus in addition to the formation of strand breaks, the methylation of DNA bases by tetracyclines is also potentially mutagenic.

Mídia Livros     Paperback Book   (Livro de capa flexível e brochura)
Lançado 3 de maio de 2011
ISBN13 9783844393224
Editoras LAP LAMBERT Academic Publishing
Páginas 120
Dimensões 150 × 7 × 226 mm   ·   197 g
Idioma German  

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