Urokinase Receptor (Upar) and Integrin Interactions in Angiogenesis: Urokinase Receptor and Integrin Interplay on Endothelial Cells and Its Implication in Vegf-induced Angiogenesis - Revu Alexander - Livros - Südwestdeutscher Verlag für Hochschulsch - 9783838133409 - 24 de maio de 2012
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Urokinase Receptor (Upar) and Integrin Interactions in Angiogenesis: Urokinase Receptor and Integrin Interplay on Endothelial Cells and Its Implication in Vegf-induced Angiogenesis

Revu Alexander

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R 968,84

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Urokinase Receptor (Upar) and Integrin Interactions in Angiogenesis: Urokinase Receptor and Integrin Interplay on Endothelial Cells and Its Implication in Vegf-induced Angiogenesis

This thesis aims at elucidating the essential role played by the urokinase receptor (uPAR) in driving VEGF induced angiogenesis. On the molecular level the formation of blood vessels from preexisting ones requires the coordinated interaction of the protease system which by their degradation of the extracellular matrix facilitates the adhesion receptors of endothelial cells to invoke migration and invasion. Using flow cytometry and immunohistochemistry based techniques we show that the protease receptor uPAR through its interaction with alpha5beta1 integrins funnels VEGF induced signals for angiogenesis. Inhibition of uPAR interaction with integrins not only impedes endothelial cell migration but also in vivo VEGF induced angiogenesis. In effect uPAR could be investigated as a potential target for angiogenesis based drug therapies.

Mídia Livros     Paperback Book   (Livro de capa flexível e brochura)
Lançado 24 de maio de 2012
ISBN13 9783838133409
Editoras Südwestdeutscher Verlag für Hochschulsch
Páginas 88
Dimensões 150 × 5 × 226 mm   ·   149 g
Idioma German