Effect of Sida on Histology of Kidney & Some Biochemical Parameters

The kidney and liver were removed, preserved and processed for paraffin sections and hematoxylin and eosin (H&E) staining. The animals in the control group showed normal histological and biochemical parameters. Conversely, animals that received 100mg/kgbw of the extract showed slight difference in their hepatic cyto-architecture while animals that were administered with 200mg/kgbw of the extract revealed distorted morphological feature showing shrunken sinusoid and dilation of the central vein suggesting that the extract has adverse effect on the morphology of the liver. The kidney histology of the animals treated with 100mg/kgbw and 200mg/kgbw of the extract revealed slight edema, necrosis of tubular cells suggesting possible adverse effect on renal function. Serum chemistry revealed significantly raised sodium and decreased potassium levels in animals treated with 100mg/kgbw, but chloride, creatinine and potassium not significantly affected (P>0.05). Animals treated with 200mg/kgbw of the extract had significantly raised sodium levels, but reduced potassium, chloride and creatinine relative to control (P<0.05). Results of the serum liver enzymes of animals treated with 100mg/kgbw