New Biotherapeutic Agents for Resolving Periodontal Inflammation: an Insight into Resolving and Other Pro Resolving Lipid Mediators

Current treatment modalities for inflammataory diseases like periodontitis aim at suppressing the inflammatory response. Resolution of inflammation was once thought to be a passive process. However, recently it has been recognized that resolution is an active process and involves the generation of various pro-resolving molecules. These mediators have antiinflammatory and pro-resolution properties that enable them to control the inflammatory responses and to stimulate resolution. The aim of this dissertation is to summarize the bioactivities of one of these pro-resolving mediators ?resolvins?, their underlying biochemical pathways and their role as future targets for resolution of inflammation in periodontal diseases.