Synthesis and Characterization of Ni & Cu Complexes: of N-pyrazolylpropanamide and Antimicrobial Activities

The ligand N-pyrazolylpropanamide and two biologically active complexes of Ni+2 and Cu+2 with N-pyrazolylpropanamide have been synthesized and characterized in the following way by Michael addition of pyrazole to acrylamide in the presence of trimethylbenzylammonium hydroxide (Triton B, 40% in methanol) as a basic catalyst. The synthesized ligand, metal salts and its complexes have been screened for their antimicrobial activities against two species of bacteria (Bacillus subtillis and Shigella) by agar diffusion method. The results showed that the metal complexes are more active than the ligand and metal salts alone against these bacterial species. In addition, the biological activity of the Cu+2 complex is more active than the Ni+2 complex against these same bacterial species.