Psychiatric Disorders: Methods and Protocols - Methods in Molecular Biology 2012 edition

Marc Notes: Includes bibliographical references and index. Review Quotes: From the reviews: This is a comprehensive compilation of in vivo and in vitro neuropsychiatric research methods and protocols on animal models and cutting-edge techniques in the wide spectrum of psychiatric illnesses. It is written for graduates, postdoctoral workers, and established scientists working on behavioral and molecular neuropsychiatric research. The detailed methods and protocols make this a quality book for any researcher in the field of neuroscience and psychiatry. (Valerie E. Mathis-Allen, Doody s Book Reviews, May, 2012)"Jacket Description/Back: New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In "Psychiatric Disorders: Methods and Protocols," key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art "Omics" approaches and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful "Methods in Molecular Biology " series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and easily applicable, "Psychiatric Disorders: Methods and Protocols" offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach."Table of Contents: Part I: Overview of the Animal Research in Psychiatric Illness and Substance Abuse 1. New Frontiers in Animal Research of Psychiatric Illness Arie Kaffman and John J. Krystal 2. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview Scott Edwards and George F. Koob 3. Qualitative Vs. Quantitative Methods in Psychiatric Research Mahdi Razafsha, Hura Behforuzi, Hassan Azari, Zhiqun Zhang, Kevin K. Wang, Firas H. Kobeissy, and Mark S. Gold Part II: Methods in Animal Models of Psychiatric Illness 4. Animal Models of Self-Injurious Behavior: An Overview Darragh P. Devine 5. Rodent Models of Adaptive Decision Making Alicia Izquierdo and Annabelle M. Belcher 6. Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis Ying Xu, Philip A. Barish, Jianchun Pan, William O. Ogle, and James M. O Donnell 7. Modeling Depression in Animal Models David H. Overstreet 8. Behavioral Model for Assessing Cognitive Decline Michael Guidi and Thomas C. Foster 9. The Pemoline Model of Self-Injurious Behavior Darragh P. Devine 10. Modeling Risky Decision Making in Rodents Nicholas W. Simon and Barry Setlow 11. Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes Abdelkader Ennaceur 12. An Animal Model to Study the Molecular Basis of Tardive Dyskinesia Mahendra Bishnoi and Ravneet K. Boparai Part III: Methods in Animal Models of Substance Abuse 13. Models of Chronic Alcohol Exposure and Dependence Darin J. Knapp and George R. Breese 14. Rat Models of Prenatal and Adolescent Cannabis Exposure Jennifer A. DiNieri and Yasmin L. Hurd 15. Modeling Nicotine Addiction in Rats Stephanie Caille, Kelly Clemens, Luis Stinus, and Martine Cador 16. Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal Rayna M. Bauzo and Adrie W. Bruijnzeel 17. Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms Firas H. Kobeissy, Jeremiah D. Mitzelfelt, Irina Fishman, Drake Morgan, Roger Gaskins, Zhiqun Zhang, Mark S Gold, and Kevin Wang 18. Cocaine Self-Administration in Rats: Hold Down Procedures Benjamin A. Zimmer and David C. S. Roberts 19. Cocaine Self-Administration in Rats: Discrete Trials Procedures Carson V. Dobrin and David C. S. Roberts 20. Cocaine Self-Administration in Rats: Threshold Procedures Erik B. Oleson and David C. S. Roberts 21. Assessing Locomotor-Stimulating Effects of Cocaine in Rodents Drake Morgan, Jameson P. DuPree, Alex D. Bibbey, and Glen M. Sizemore 22. Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure Joy Guingab-Cagmat, Rayna M. Bauzo, Adrie W. Bruijnzeel, Kevin Wang, Mark S. Gold, and Firas H. Kobeissy Part IV: Methods in Animal Models of Eating Disorders 23. Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight Nicole M. Avena, Miriam E. Bocarsly, and Bartley G. Hoebel 24. Animal Models of Overeating Neil E. Rowland 25. The Activity-Based Anorexia Mouse Model Stephanie J. Klenotich and Stephanie C. Dulawa Part V: Biomarkers, Neuroendocrine and Inflammatory Profiles Relevant to Neuropsychiatric Disorders 26. Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models Amy S. Kohtz and Cheryl A. Frye 27. Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders John M. Petitto, Zhi Huang, Danielle Meola, Grace K. Ha, and Daniel Dauer 28. Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines Hiroyuki Nawa and Kiyofumi Yamada 29. P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD) Lei Zhang and He Li Part VI: " Omics " Analysis and Systems Biology Applications in Psychiatric Disorders 30. Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure Antoniette M. Maldonado-Devincci, Stanley M. Stevens, Jr., and Cheryl L. Kirstein 31. Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders Julia S. Gelman, Jonathan Wardman, Vadiraja B. Bhat, Fabio C. Gozzo, and Lloyd D. Fricker 32. ADHD Animal Model Characterization: Transcriptomics and Proteomics Analyses Yoshinori Masuo, Junko Shibato, and Randeep Rakwal 33. Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics Michaela D. Filiou and Christoph W. Turck 34. Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research Pietro Paolo Sanna, Vez Repunte-Canonigo, and Alessandro Guidotti 35. Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia Bin Liu, David S. Barber, and Stanley M. Stevens, Jr. 36. Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations Felix Tretter and Peter J. Gebicke-Haerter 37. Data Mining in Psychiatric Research Diego Tovar, Eduardo Cornejo, Petros Xanthopoulos, Mario R. Guarracino, and Panos M. Pardalos"